Global sequence variation in the histidine-rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic tests.

doi:10.1186/1475-2875-9-129

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Article

Global sequence variation in the histidine-rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic tests.

Malaria journal - 17 May 2010

Baker Joanne, Ho Mei-Fong, Pelecanos Anita, Gatton Michelle, Chen Nanhua, Abdullah Salim, Albertini Audrey, Ariey Frederic, Barnwell John, Bell David, Cunningham Jane, Djalle Djibrine, Echeverry Diego F, Gamboa Dionicia, Hii Jeffery, Kyaw Myat Phone, Luchavez Jennifer, Membi Christopher, Menard Didier, Murillo Claribel, Nhem Sina, Ogutu Bernhards, Onyor Pamela, Oyibo Wellington, Wang Shan Qing, McCarthy James, Cheng Qin

Abstract excerpt

BACKGROUND: Accurate diagnosis is essential for prompt and appropriate treatment of malaria. While rapid diagnostic tests (RDTs) offer great potential to improve malaria diagnosis, the sensitivity of RDTs has been reported to be highly variable. One possible factor contributing to variable test performance is the diversity of parasite antigens. This is of particular concern for Plasmodium falciparum...

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PMID: 20470441
DOI: 10.1186/1475-2875-9-129
PMCID: PMC2893195

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