Article
Mutual cross-interference between glucocorticoid receptor and CREB inhibits transactivation in placental cells.
The New biologist - 1 May 1992
Stauber C, Altschmied J, Akerblom I E, Marron J L, Mellon P L
Abstract excerpt
Transcription of the glycoprotein hormone alpha-subunit gene in placental cells is repressed by glucocorticoids, an effect that is mediated through the glucocorticoid receptor (GR). Although the DNA-binding domain of GR has been shown to be important, mutation of the previously identified GR-binding sites in the alpha-subunit promoter fails to abolish repression. Furthermore, mutant receptors in which the...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Line
- Cyclic AMP Response Element-Binding Protein
- DNA
- DNA-Binding Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Placenta