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Article

A complement receptor-1 polymorphism with high frequency in malaria endemic regions of Asia but not Africa.

Genes and immunity - 1 Feb 2005

Thomas B N, Donvito B, Cockburn I, Fandeur T, Rowe J A, Cohen J H M, Moulds J M

Abstract excerpt

Complement receptor-1 (CR1) is a ligand for rosette formation, a phenomenon associated with cerebral malaria (CM). Binding is dependent on erythrocyte CR1 copy number. In Caucasians, low CR1 expressors have two linked mutations. We determined the Q981H and HindIII RFLP distribution in differing population groups to ascertain a possible role in adaptive evolution. We examined 194 Caucasians, 180 Choctaw Indians,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15578041
DOI: 10.1038/sj.gene.6364150
PMCID: PMC2877660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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