Article
Survival and proliferation of CD28- T cells during HIV-1 infection relate to the amplitude of viral replication.
The Journal of infectious diseases - 1 Jun 2011
Vivar Nancy, Ruffin Nicolas, Sammicheli Stefano, Hejdeman Bo, Rethi Bence, Chiodi Francesca
Abstract excerpt
BACKGROUND: CD28(-) T lymphocytes progressively increase during aging, autoimmunity, and HIV-1 infection. Expansion of these cells stands in contrast with their senescent phenotype described by several studies. Understanding the functional properties and phenotype of CD28(-) T cell during HIV-1 infection is important, because this subset incorporates T cells specific for HIV-1 and other chronic pathogens....
Topics
- Anti-Retroviral Agents
- Apoptosis
- CD28 Antigens
- Case-Control Studies
- Cell Differentiation
- Cytokines
- Flow Cytometry
- HIV Infections
- HIV-1
- Humans
- Interleukin-2 Receptor alpha Subunit
- Lymphocyte Activation
- Perforin
- Phenotype