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Article

Programmed Death of T Cells in HIV-1 Infection

10 Jul 1992

Abstract excerpt

In human immunodeficiency virus (HIV) infection, functional defects and deletion of antigen-reactive T cells are more frequent than can be explained by direct viral infection. On culturing, both CD4+ and CD8+ T cells from asymptomatic HIV-infected individuals died as a result of programmed cell death (apoptosis). Apoptosis was enhanced by activation with CD3 antibodies. Programmed cell death, associated with...

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PMID: 1352911
DOI: 10.1126/science.1352911

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