Article
Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes.
The Journal of infectious diseases - 15 Jun 2003
Kalayjian Robert C, Landay Alan, Pollard Richard B, Taub Dennis D, Gross Barry H, Francis Isaac R, Sevin Anne, Pu Minya, Spritzler John, Chernoff Miriam, Namkung Ann, Fox Lawrence, Martinez Ana, Waterman Karen, Fiscus Susan A, Sha Beverly, Johnson Debra, Slater Stanley, Rousseau Frank, Lederman Michael M
Abstract excerpt
Older age is a strong predictor of accelerated human immunodeficiency virus (HIV) disease progression. We investigated the possible immunologic basis of this interaction by comparing older (>/=45 years) and younger (</=30 years) HIV-infected adults with simultaneously enrolled, aged-matched, healthy volunteers. Cross-sectional comparisons suggested age-associated reductions in naive CD8(+) cells and in the...
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