Article
Markers of cell death-activation in lymphocytes of vertically HIV-infected children naive to highly active antiretroviral therapy: the role of age.
The Journal of allergy and clinical immunology - 1 Sept 2001
Viganò A, Pinti M, Nasi M, Moretti L, Balli F, Mussini C, Bricalli D, Sala N, Bugarini R, Vella S, Principi N, Cossarizza A
Abstract excerpt
BACKGROUND: Apoptosis plays a major role in depleting CD4(+) lymphocytes during infection with HIV-1. Few data exist on its role during HIV infection of children. Sensitivity of peripheral blood lymphocytes (PBLs) to apoptotic stimuli and the importance of the patient's age remain unclear. OBJECTIVES: We sought to analyze the following: (1) markers of cell death-activation (CD95, CD45 isoforms, and CD28) in PBLs...
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