Article
Causal graph-based analysis of genome-wide association data in rheumatoid arthritis.
Biology direct - 18 May 2011
Alekseyenko Alexander V, Lytkin Nikita I, Ai Jizhou, Ding Bo, Padyukov Leonid, Aliferis Constantin F, Statnikov Alexander
Abstract excerpt
BACKGROUND: GWAS owe their popularity to the expectation that they will make a major impact on diagnosis, prognosis and management of disease by uncovering genetics underlying clinical phenotypes. The dominant paradigm in GWAS data analysis so far consists of extensive reliance on methods that emphasize contribution of individual SNPs to statistical association with phenotypes. Multivariate methods, however, can...
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