Article
A potential role of TNFR gene polymorphisms in autoimmune thyroid diseases in the Tunisian population.
Cytokine - 1 Aug 2008
Kammoun-Krichen Maha, Bougacha-Elleuch Noura, Makni Kaouthar, Mnif Mouna, Jouida Joumaa, Abid Mohamed, Rebai Ahmed, Ayadi Hammadi
Abstract excerpt
Autoimmune thyroid diseases (AITDs) including Graves disease (GD) and autoimmune hypothyroidism (AH) are associated with TNF genes polymorphisms. TNF molecules bind to TNFRI and TNFRII. No genetic association was reported between TNFR and AITDs. In this study, we have analysed two polymorphisms in TNFRI gene (TNFRI+36A/G SNP and a microsatellite (GT)(17) (GA)(n)) and one polymorphism in TNFRII gene (TNFRII +676...
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