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Article

Establishment of a karyotypically normal B-chronic lymphocytic leukemia cell line; evidence of leukemic origin by immunoglobulin gene rearrangement.

Leukemia research - 1 Jan 1990

Saltman D, Bansal N S, Ross F M, Ross J A, Turner G, Guy K

Abstract excerpt

A new Epstein-Barr virus (EBV) transformed cell line was established from a patient with B-chronic lymphocytic leukemia (B-CLL). The karyotype of the cell line has remained normal for over 12 months in culture; however, identical heavy and light chain immunoglobulin (Ig) gene rearrangements in the patient's blood and the cell line provided evidence that the EBV transformed cells were derived from the neoplastic...

Topics

Aged
Blotting, Southern
Cell Transformation, Viral
Female
Gene Rearrangement
Genes, Immunoglobulin
Herpesvirus 4, Human
Humans
Karyotyping
Leukemia, Lymphocytic, Chronic, B-Cell
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Source

Identifiers

PMID: 2159091
DOI: 10.1016/0145-2126(90)90167-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2159091-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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