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Article

ABCA3 is critical for lamellar body biogenesis in vivo.

The Journal of biological chemistry - 17 Aug 2007

Cheong Naeun, Zhang Huayan, Madesh Muniswamy, Zhao Ming, Yu Kevin, Dodia Chandra, Fisher Aron B, Savani Rashmin C, Shuman Henry

Abstract excerpt

Mutations in ATP-binding cassette transporter A3 (human ABCA3) protein are associated with fatal respiratory distress syndrome in newborns. We therefore characterized mice with targeted disruption of the ABCA3 gene. Homozygous Abca3-/- knock-out mice died soon after birth, whereas most of the wild type, Abca3+/+, and heterozygous, Abca3+/-, neonates survived. The lungs from E18.5 and E19.5 Abca3-/- mice were less...

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Share to ATP-Binding Cassette Transporters
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Phospholipids

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Share to Pulmonary Surfactant-Associated Protein B

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Source

Identifiers

PMID: 17540762
DOI: 10.1074/jbc.M703927200

Genes

ABCA3

Provenance

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ABCA3 is critical for lamellar body biogenesis in vivo.PMID 17540762Read ↗

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Targeted inactivation of the murine Abca3 gene leads to respiratory failure in newborns with defective lamellar bodiesSemantic proximity Read ↗

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