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Article

A SINE insertion provides information on the divergence of the HLA-DQA1 and HLA-DQA2 genes.

Immunogenetics - 1 Jan 1990

Del Pozzo G, Guardiola J

Abstract excerpt

The class II region of the human major histocompatibility complex (MHC) contains a cluster of highly polymorphic genes organized into at least three subloci (DR, DQ, and DP), each encoding a subset of surface antigens participating in the modulation of the immune response. Genetic diversity in this system is brought about by two major mechanisms, hypermutation and trans-species evolution. The DQ subregion...

Topics

Animals
Biological Evolution
Cloning, Molecular
DNA Transposable Elements
Gene Expression
Genetic Variation
HLA-DQ Antigens
Histocompatibility Antigens Class II
Humans
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repetitive Sequences, Nucleic Acid

Source

Identifiers

PMID: 2158485
DOI: 10.1007/BF00204892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2158485-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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