Article
An ancient interlocus recombination increases class II MHC DQA diversity in sheep and other Bovidae.
Animal genetics - 1 Jun 2015
Ballingall Keith T, Steele Philip, Lantier Isabelle, Cotelli Matteo, Todd Helen, Lopez Guido, Martin Elena, Lantier Frederic
Abstract excerpt
Animals with fully characterised major histocompatibility complex (MHC) regions are often used to explore the molecular interactions that control the induction of adaptive immunity. The ovine MHC includes two DQA loci, termed DQA1 and DQA2. However, in a minority of haplotypes the DQA1 locus appears absent (DQA1 null) and is replaced by a second locus termed, DQA2-like. This raises a number of questions regarding...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Biological Evolution
- Cattle
- Genes, MHC Class II
- Goats
- Haplotypes
- Molecular Sequence Data
- Phylogeny
- Recombination, Genetic
- Sequence Analysis, DNA
- Sheep, Domestic