Segmental exchange between MHC class I genes in a higher primate: recombination in the gorilla between the ancestor of a human non-functional gene and an A locus gene.

doi:10.1007/BF00205822

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Article

Segmental exchange between MHC class I genes in a higher primate: recombination in the gorilla between the ancestor of a human non-functional gene and an A locus gene.

Immunogenetics - 1 Jan 1991

Watkins D I, Chen Z W, Garber T L, Hughes A L, Letvin N L

Abstract excerpt

Classical human major histocompatibility complex (MHC) class I molecules are the products of highly diverse gene loci. It has been suggested that segmental exchange may play a role in the generation of diversity at the antigen recognition site of MHC class I molecules. Here we present the cloning...

Topics

Animals
Base Sequence
Chromosome Mapping
Genes, MHC Class I
Genetic Variation
Gorilla gorilla
Molecular Sequence Data
Recombination, Genetic

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