The effect of novobiocin on yeast topoisomerase type II.

doi:10.1007/BF00260491

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Article

The effect of novobiocin on yeast topoisomerase type II.

Molecular & general genetics : MGG - 1 Jan 1990

Pocklington M J, Jenkins J R, Orr E

Abstract excerpt

Low concentrations of novobiocin are toxic to permeable yeast cells, but do not inhibit type II topoisomerase activity. Furthermore, the enzyme does not bind specifically to novobiocin-Sepharose. These observations are in agreement with genetical analyses. Mutations at a single locus that confer...

Topics

Chromatography, Affinity
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Electrophoresis, Polyacrylamide Gel
Microscopy, Fluorescence
Mutation
Novobiocin
Saccharomyces cerevisiae
Temperature

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