Article
The effect of novobiocin on yeast topoisomerase type II.
Molecular & general genetics : MGG - 1 Jan 1990
Pocklington M J, Jenkins J R, Orr E
Abstract excerpt
Low concentrations of novobiocin are toxic to permeable yeast cells, but do not inhibit type II topoisomerase activity. Furthermore, the enzyme does not bind specifically to novobiocin-Sepharose. These observations are in agreement with genetical analyses. Mutations at a single locus that confer novobiocin resistance and temperature sensitivity exhibit a similar phenotype to cells treated with novobiocin, but are...
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