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Keratinocyte Growth Factor Expression by Fibroblasts in Pulmonary Fibrosis

27 Jan 2005

Abstract excerpt

Keratinocyte growth factor (KGF) is secreted by fibroblasts and protects from pulmonary fibrosis in animal models. Interleukin (IL)-1beta is the most potent inducer of KGF in fibroblasts, acting through the c-Jun pathway. We evaluated in vitro KGF production by human lung fibroblasts from patients with idiopathic pulmonary fibrosis (IPF, n = 10) and from control subjects (n = 7) at baseline and after IL-1beta...

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PMID: 15677771
DOI: 10.1165/rcmb.2004-0205oc

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