Article
YB-1 activating cascades as potential targets in KRAS-mutated tumors.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] - 1 Dec 2023
Khozooei Shayan, Veerappan Soundaram, Toulany Mahmoud
Abstract excerpt
Y‑box binding protein‑1 (YB-1) is a multifunctional protein that is highly expressed in human solid tumors of various entities. Several cellular processes, e.g. cell cycle progression, cancer stemness and DNA damage signaling that are involved in the response to chemoradiotherapy (CRT) are tightly governed by YB‑1. KRAS gene with about 30% mutations in all cancers, is considered the most commonly mutated oncogene...
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