Article
Detection of somatic mutations in tumours of diverse types by DNA fingerprinting with M13 phage DNA.
International journal of cancer - 15 Apr 1990
Hayward N, Chen P, Nancarrow D, Kearsley J, Smith P, Kidson C, Ellem K
Abstract excerpt
Hybridization of M13 phage DNA to Southern blots of human DNA produces an individual-specific DNA fingerprint. In this study, tumour and lymphocyte DNA from a series of patients with melanoma, Merkel-cell carcinoma, Burkitt's lymphoma and Wilms' tumour was probed with M13 DNA to detect somatic mu...
Topics
- Bacteriophages
- Blotting, Southern
- Burkitt Lymphoma
- Carcinoma, Merkel Cell
- DNA Mutational Analysis
- DNA Probes
- DNA, Neoplasm
- Humans
- Melanoma
- Mutation
- Skin Neoplasms
- Wilms Tumor