Detection of somatic mutations in tumours of diverse types by DNA fingerprinting with M13 phage DNA.

doi:10.1002/ijc.2910450420

Back to search

Article

Detection of somatic mutations in tumours of diverse types by DNA fingerprinting with M13 phage DNA.

International journal of cancer - 15 Apr 1990

Hayward N, Chen P, Nancarrow D, Kearsley J, Smith P, Kidson C, Ellem K

Abstract excerpt

Hybridization of M13 phage DNA to Southern blots of human DNA produces an individual-specific DNA fingerprint. In this study, tumour and lymphocyte DNA from a series of patients with melanoma, Merkel-cell carcinoma, Burkitt's lymphoma and Wilms' tumour was probed with M13 DNA to detect somatic mutations in the DNA of the tumours. Somatic changes were observed in tumour DNA of 16 out of the 28 cases examined. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Neoplasm

Share to DNA Probes

Share to Melanoma

Share to Mutation

Share to Skin Neoplasms

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 8 closest

Detection of somatic mutations in tumours of diverse types by DNA fingerprinting with M13 phage DNA.PMID 2157675Read

Clonal analysis of precancerous lesion of hepatocellular carcinoma.Semantic proximity Read

Somatic mitochondrial mutations in melanoma resection specimens.Semantic proximity Read

A comprehensive catalogue of somatic mutations from a human cancer genome.Semantic proximity Read

Somatic mutations provide important and unique insights into the biology of complex diseases.Semantic proximity Read

Human cancers express mutator phenotypes: origin, consequences and targeting.Semantic proximity Read

Mechanisms underlying mutational signatures in human cancers.Semantic proximity Read

Evolutionary mechanisms and diversity in cancer.Semantic proximity Read

Somatic mutations, genome mosaicism, cancer and aging.Semantic proximity Read