Article
Somatic mitochondrial mutations in melanoma resection specimens.
International journal of oncology - 1 Jan 2004
Deichmann Martin, Kahle Birgit, Benner Axel, Thome Marianne, Helmke Burkhard, Näher Helmut
Abstract excerpt
As epidemiological data suggest ultraviolet (UV) radiation to be the major environmental factor for the development of melanoma, we screened this malignancy for UV-specific C right curved arrow T and CC right curved arrow TT DNA mutations as described in squamous and basal cell carcinomas of the skin. Mitochondrial (mt) DNA was addressed which is known to be highly more susceptible for mutations than nuclear DNA....
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