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Article

Type IV pilins regulate their own expression via direct intramembrane interactions with the sensor kinase PilS.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 2016

Kilmury Sara L N, Burrows Lori L

Abstract excerpt

Type IV pili are important virulence factors for many pathogens, including Pseudomonas aeruginosa Transcription of the major pilin gene-pilA-is controlled by the PilS-PilR two-component system in response to unknown signals. The absence of a periplasmic sensing domain suggested that PilS may sense an intramembrane signal, possibly PilA. We suggest that direct interactions between PilA and PilS in the inner...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27162347
DOI: 10.1073/pnas.1512947113
PMCID: PMC4889343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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