Article
ENPP1 affects insulin action and secretion: evidences from in vitro studies.
PloS one - 5 May 2011
Di Paola Rosa, Caporarello Nunzia, Marucci Antonella, Dimatteo Claudia, Iadicicco Claudia, Del Guerra Silvia, Prudente Sabrina, Sudano Dora, Miele Claudia, Parrino Cristina, Piro Salvatore, Beguinot Francesco, Marchetti Piero, Trischitta Vincenzo, Frittitta Lucia
Abstract excerpt
The aim of this study was to deeper investigate the mechanisms through which ENPP1, a negative modulator of insulin receptor (IR) activation, plays a role on insulin signaling, insulin secretion and eventually glucose metabolism. ENPP1 cDNA (carrying either K121 or Q121 variant) was transfected in HepG2 liver-, L6 skeletal muscle- and INS1E beta-cells. Insulin-induced IR-autophosphorylation (HepG2, L6, INS1E),...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.