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Article

The role of the Niemann-Pick disease, type C1 protein in adipocyte insulin action.

PloS one - 1 Jan 2014

Fletcher Rachael, Gribben Christopher, Ma Xiuquan, Ma Xuiquan, Burchfield James G, Thomas Kristen C, Krycer James R, James David E, Fazakerley Daniel J

Abstract excerpt

The Niemann-Pick disease, type C1 (NPC1) gene encodes a transmembrane protein involved in cholesterol efflux from the lysosome. SNPs within NPC1 have been associated with obesity and type 2 diabetes, and mice heterozygous or null for NPC1 are insulin resistant. However, the molecular mechanism underpinning this association is currently undefined. This study aimed to investigate the effects of inhibiting NPC1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24752197
DOI: 10.1371/journal.pone.0095598
PMCID: PMC3994084

Genes

NPC1

Provenance

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