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Article

Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family.

PLoS pathogens - 1 May 2011

Janes Joel H, Wang Christopher P, Levin-Edens Emily, Vigan-Womas Inès, Guillotte Micheline, Melcher Martin, Mercereau-Puijalon Odile, Smith Joseph D

Abstract excerpt

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family plays a central role in antigenic variation and cytoadhesion of P. falciparum infected erythrocytes. PfEMP1 proteins/var genes are classified into three main subfamilies (UpsA, UpsB, and UpsC) that are hypothesized to have different roles in binding and disease. To investigate whether these subfamilies have diverged in binding specificity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21573138
DOI: 10.1371/journal.ppat.1002032
PMCID: PMC3088720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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