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Structural insights into diverse modes of ICAM-1 binding by Plasmodium falciparum -infected erythrocytes

16 Sept 2019

Abstract excerpt

is the adhesion of parasite-infected erythrocytes to the vasculature or tissues of infected individuals. This occludes blood flow, leads to inflammation, and increases parasitemia by reducing spleen-mediated clearance of the parasite. This adhesion is mediated by PfEMP1, a multivariant family of around 60 proteins per parasite genome which interact with specific host receptors. One of the most common of these...

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PMID: 31527263
DOI: 10.1073/pnas.1911900116

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