Article
Rescue of the learning defect in dunce, a Drosophila learning mutant, by an allele of rutabaga, a second learning mutant.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990
Feany M B
Abstract excerpt
rutabaga1 (rut1), a Drosophila learning mutant, has adenylate cyclase (EC 4.6.1.1) with reduced basal activity and the absence of calcium/calmodulin-stimulated activity. A second learning mutant, dunce, is defective in cyclic AMP degradation due to decreased or absent phosphodiesterase activity. These opposing biochemical defects allow rut1 to partially suppress the female sterility caused by elevated cyclic AMP...
Topics
- 3',5'-Cyclic-AMP Phosphodiesterases
- Adenylyl Cyclases
- Alleles
- Animals
- Cyclic AMP
- Drosophila
- Genotype
- Learning
- Mutation