Article
Conditional rescue of the dunce learning/memory and female fertility defects with Drosophila or rat transgenes.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 May 1995
Dauwalder B, Davis R L
Abstract excerpt
Mutations in the Drosophila dunce gene, the structural gene for a cAMP-specific phosphodiesterase (PDE), disrupt normal learning and memory and lead to female sterility. Our experiments address a long-standing question in the genetic dissection of learning and memory of whether dnc is involved in...
Topics
- 3',5'-Cyclic-AMP Phosphodiesterases
- Animals
- Animals, Genetically Modified
- Base Sequence
- Cell Line, Transformed
- Crosses, Genetic
- DNA Transposable Elements
- Drosophila
- Female
- Fertility
- Gene Expression
- Genes
- Genotype
- Heat-Shock Proteins
- Hot Temperature
- Infertility, Female
- Kinetics
- Learning