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Article

Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade.

Science (New York, N.Y.) - 11 Jan 1991

Zhong Y, Wu C F

Abstract excerpt

Synaptic transmission was examined in Drosophila mutants deficient in memory function. These mutants, dunce and rutabaga, are defective in different steps of the cyclic adenosine 3',5'-monophosphate (cAMP) cascade. In both dunce and rutabaga larvae, voltage-clamp analysis of neuromuscular transmission revealed impaired synaptic facilitation and post-tetanic potentiation as well as abnormal responses to direct...

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PMID: 1670967
DOI: 10.1126/science.1670967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade.PMID 1670967Read ↗

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Adaptation and fatigue of a mechanosensory neuron in wild-type Drosophila and in memory mutants.Semantic proximity Read ↗

Reduced growth cone motility in cultured neurons from Drosophila memory mutants with a defective cAMP cascade.Semantic proximity Read ↗

Regional calcium regulation within cultured Drosophila neurons: effects of altered cAMP metabolism by the learning mutations dunce and rutabaga.Semantic proximity Read ↗

Alterations in frequency coding and activity dependence of excitability in cultured neurons of Drosophila memory mutants.Semantic proximity Read ↗

Synaptic ultrastructure in nerve terminals of Drosophila larvae overexpressing the learning gene dunce.Semantic proximity Read ↗

Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants.Semantic proximity Read ↗

Increased calcium influx through acetylcholine receptors in dunce neurons.Semantic proximity Read ↗

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