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Article

Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade.

Science (New York, N.Y.) - 11 Jan 1991

Zhong Y, Wu C F

Abstract excerpt

Synaptic transmission was examined in Drosophila mutants deficient in memory function. These mutants, dunce and rutabaga, are defective in different steps of the cyclic adenosine 3',5'-monophosphate (cAMP) cascade. In both dunce and rutabaga larvae, voltage-clamp analysis of neuromuscular transmission revealed impaired synaptic facilitation and post-tetanic potentiation as well as abnormal responses to direct...

Topics

Action Potentials
Animals
Bucladesine
Calcium
Cyclic AMP
Drosophila
Electric Stimulation
Larva
Memory
Muscle Contraction
Mutation
Neuromuscular Junction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuronal Plasticity

Neurotransmitter Agents

Synapses

Source

Identifiers

PMID: 1670967
DOI: 10.1126/science.1670967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1670967-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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