Article
Clonal variation in gene methylation: c-H-ras and alpha-hCG regions vary independently in human fibroblast lineages.
Mutation research - 1 Jan 1990
Shmookler Reis R J, Finn G K, Smith K, Goldstein S
Abstract excerpt
The stability of DNA methylation has been followed in clonal lineages of human diploid fibroblasts, for the gene regions encoding the c-H-ras proto-oncogene and the alpha subunit of human chorionic gonadotropin (alpha-hCG). Although methylation losses predominated, both de novo gains and losses o...
Topics
- Cell Survival
- Chorionic Gonadotropin
- Clone Cells
- Cytosine
- DNA
- DNA Probes
- DNA Restriction Enzymes
- Electrophoresis, Agar Gel
- Female
- Fibroblasts
- Genes, ras
- Genetic Variation
- Humans
- Methylation
- Proto-Oncogene Mas
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins p21(ras)
- Restriction Mapping