Article
Clonal variation in gene methylation: c-H-ras and alpha-hCG regions vary independently in human fibroblast lineages.
Mutation research - 1 Jan 1990
Shmookler Reis R J, Finn G K, Smith K, Goldstein S
Abstract excerpt
The stability of DNA methylation has been followed in clonal lineages of human diploid fibroblasts, for the gene regions encoding the c-H-ras proto-oncogene and the alpha subunit of human chorionic gonadotropin (alpha-hCG). Although methylation losses predominated, both de novo gains and losses of cytosine methylation were observed in subclones and sub-subclones, at frequencies which differed between individual...
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