Article
Analysis of androgen receptor DNA reveals the independent clonal origins of uterine leiomyomata and the secondary nature of cytogenetic aberrations in the development of leiomyomata.
Genes, chromosomes & cancer - 1 Sept 1994
Mashal R D, Fejzo M L, Friedman A J, Mitchner N, Nowak R A, Rein M S, Morton C C, Sklar J
Abstract excerpt
Uterine leiomyomata are thought to be monoclonal neoplasms. Accordingly, investigations of clonality with G6PD isoforms used as a marker for X chromosome inactivation have suggested independent origins for multiple tumors within individual uteri. However, results from a recent study assessing met...
Topics
- Alleles
- Base Sequence
- Chromosome Aberrations
- Clone Cells
- DNA, Neoplasm
- Dosage Compensation, Genetic
- Female
- Humans
- Karyotyping
- Leiomyomatosis
- Minisatellite Repeats
- Molecular Sequence Data
- Neoplasm Proteins
- Neoplastic Stem Cells