Article
Human Prolactin Gene Expression: Positive Correlation between Site-Specific Methylation and Gene Activity in a Set of Human Lymphoid Cell Lines*
1 Dec 1990
Abstract excerpt
From the human B-lymphoblastoid cell line IM-9-P, we derived the IM-9-P series of clonal sublines that differ from each other in the degree of human PRL (hPRL) production. To elucidate the mechanisms underlying the different levels of hPRL gene activity in these cell lines, we investigated the methylation status of the gene, since the methylation pattern of cytosine-residues in CpG dinucleotides has been...
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