Partial or complete blocking of gD binding to HVEM affects primary and latent HSV-1 infection as well as eye disease in HSV-1 infected mice.

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) engages herpesvirus entry mediator (HVEM) and other cellular receptors to mediate efficient viral attachment. We recently identified gD amino acids (aa) Q27-T29 as critical to completely block gD binding to HVEM, while the single Q27P mutation in gD reduced its binding to HVEM by approximately 80%. Thus, we constructed two mutant viruses: one with a single...

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