Article
Transcriptional landscape of bone marrow-derived very small embryonic-like stem cells during hypoxia.
Respiratory research - 10 May 2011
Gharib Sina A, Khalyfa Abdelnaby, Kucia Magdalena J, Dayyat Ehab A, Kim Jinkwan, Clair Heather B, Gozal David
Abstract excerpt
BACKGROUND: Hypoxia is a ubiquitous feature of many lung diseases and elicits cell-specific responses. While the effects of hypoxia on stem cells have been examined under in vitro conditions, the consequences of in vivo oxygen deprivation have not been studied. METHODS: We investigated the effects of in vivo hypoxia on a recently characterized population of pluripotent stem cells known as very small...
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