Article
Familial aggregation of parkinsonism in progressive supranuclear palsy.
Neurology - 14 Jul 2009
Donker Kaat L, Boon A J W, Azmani A, Kamphorst W, Breteler M M B, Anar B, Heutink P, van Swieten J C
Abstract excerpt
BACKGROUND: Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disorder characterized by aggregates of the microtubule-associated protein tau (MAPT). A nonsignificant trend for positive family history has been observed in two case-control studies and several pedigrees with familial clustering of parkinsonism have been described. Occasionally, mutations in MAPT are found in patients with a...
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