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Article

Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.

Journal of medicinal chemistry - 14 Jul 2011

Chung Suhman, Himmel Daniel M, Jiang Jian-Kang, Wojtak Krzysztof, Bauman Joseph D, Rausch Jason W, Wilson Jennifer A, Beutler John A, Thomas Craig J, Arnold Eddy, Le Grice Stuart F J

Abstract excerpt

The α-hydroxytroplone, manicol (5,7-dihydroxy-2-isopropenyl-9-methyl-1,2,3,4-tetrahydro-benzocyclohepten-6-one), potently and specifically inhibits ribonuclease H (RNase H) activity of human immunodeficiency virus reverse transcriptase (HIV RT) in vitro. However, manicol was ineffective in reducing virus replication in culture. Ongoing efforts to improve the potency and specificity over the lead compound led us...

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Identifiers

PMID: 21568335
DOI: 10.1021/jm2000757
PMCID: PMC3133734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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