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Article

Synthesis and biological evaluations of sulfanyltriazoles as novel HIV-1 non-nucleoside reverse transcriptase inhibitors.

Bioorganic & medicinal chemistry letters - 15 Aug 2006

Wang Zhiwei, Wu Baogen, Kuhen Kelli L, Bursulaya Badry, Nguyen Truc N, Nguyen Deborah G, He Yun

Abstract excerpt

A novel sulfanyltriazole was discovered as an HIV-1 non-nucleoside reverse transcriptase inhibitor via HTS using a cell-based assay. Chemical modifications and molecular modeling studies were carried out to establish its SAR and understand its interactions with the enzyme. These modifications led to the identification of sulfanyltriazoles with low nanomolar potency for inhibiting HIV-1 replication and promising...

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Identifiers

PMID: 16781149
DOI: 10.1016/j.bmcl.2006.05.096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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