Article
Entropy-driven mechanism of an E3 ligase.
Biochemistry - 28 Jun 2011
Truong Khue, Su Yang, Song Jing, Chen Yuan
Abstract excerpt
Ubiquitin-like modifications are macromolecular chemistry for which our understanding of the enzymatic mechanisms is lacking. Most E3 ligases in ubiquitin-like modifications do not directly participate in chemistry but are thought to confer allosteric effects; however, the nature of the allosteric effects has been elusive. Recent molecular dynamics simulations suggested that an E3 binding enhances the population...
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