Article
Thermodynamics of Ras/effector and Cdc42/effector interactions probed by isothermal titration calorimetry.
The Journal of biological chemistry - 29 Jun 2001
Rudolph M G, Linnemann T, Grunewald P, Wittinghofer A, Vetter I R, Herrmann C
Abstract excerpt
Proliferation, differentiation, and morphology of eucaryotic cells is regulated by a large network of signaling molecules. Among the major players are members of the Ras and Rho/Rac subfamilies of small GTPases that bind to different sets of effector proteins. Recognition of multiple effectors is important for communicating signals into different pathways, leading to the question of how an individual GTPase...
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