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Article

Nitrosative damage to free and zinc‐bound cysteine thiols underlies nitric oxide toxicity in wild‐type Borrelia burgdorferi

12 May 2011

Abstract excerpt

Borrelia burgdorferi encounters potentially harmful reactive nitrogen species (RNS) throughout its infective cycle. In this study, diethylamine NONOate (DEA/NO) was used to characterize the lethal effects of RNS on B. burgdorferi. RNS produce a variety of DNA lesions in a broad spectrum of microbial pathogens; however, levels of the DNA deamination product, deoxyinosine, and the numbers of apurinic/apyrimidinic...

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Identifiers

PMID: 21564333
DOI: 10.1111/j.1365-2958.2011.07691.x

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