Article
A conservative amino acid change alters the function of BosR, the redox regulator of Borrelia burgdorferi.
Molecular microbiology - 1 Dec 2004
Seshu J, Boylan Julie A, Hyde Jenny A, Swingle Kristen L, Gherardini Frank C, Skare Jonathan T
Abstract excerpt
Borrelia burgdorferi, the aetiologic agent of Lyme disease, modulates gene expression in response to changes imposed by its arthropod vector and mammalian hosts. As reactive oxygen species (ROS) are known to vary in these environments, we asked how B. burgdorferi responds to oxidative stress. The B. burgdorferi genome encodes a PerR homologue (recently designated BosR) that represses the oxidative stress response...
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