Article
Toll-like receptor-mediated signaling in human adipose-derived stem cells: implications for immunogenicity and immunosuppressive potential.
Tissue engineering. Part A - 1 Jul 2009
Lombardo Eleuterio, DelaRosa Olga, Mancheño-Corvo Pablo, Menta Ramón, Ramírez Cristina, Büscher Dirk
Abstract excerpt
Human adipose-derived stem cells (hASCs) are mesenchymal stem cells with reduced immunogenicity and the capability to modulate immune responses. These properties make hASCs of special interest as therapeutic agents in the settings of chronic inflammatory and autoimmune diseases. Exogenous and endogenous toll-like receptor (TLR) ligands have been linked with the perpetuation of inflammation in a number of chronic...
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