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Article

Copy number variation in glutathione S-transferases M1 and T1 and ischemic vascular disease: four studies and meta-analyses.

Circulation. Cardiovascular genetics - 1 Aug 2011

Nørskov Marianne S, Frikke-Schmidt Ruth, Loft Steffen, Sillesen Henrik, Grande Peer, Nordestgaard Børge G, Tybjaerg-Hansen Anne

Abstract excerpt

BACKGROUND: Glutathione S-transferases (GSTs) M1 and T1 detoxify products of oxidative stress and may protect against atherosclerosis and ischemic vascular disease (IVD). We tested the hypothesis that copy number variation (CNV) in GSTM1 and GSTT1 genes, known to be associated with stepwise decreases in catalytic activity, predict risk of IVD. METHODS AND RESULTS: We included 23 059 Danes from 2 general...

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Source

Identifiers

PMID: 21562205
DOI: 10.1161/CIRCGENETICS.111.959809

Genes

GSTM1
GSTT1
IVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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