[Colonic polyposis and cancers of the colon. Molecular markers, predisposition and diagnosis of familial forms].

Abstract excerpt

Five to 10% of colorectal carcinomas are obvious inherited familial syndromes. The inherited molecular basis of the predisposition is uniformly present in normal cells of such patients. The identification of the genes underlying cancers, performed with the intent to clone, would first serve as a basis for a pre-symptomatic diagnosis. The APC gene, located on the long arm of chromosome 5, is the only molecular...

Topics

• Adenomatous Polyposis Coli
• Alleles
• Chromosomes, Human, Pair 5
• Colonic Neoplasms
• Cytogenetics
• Genetic Markers
• Humans
• Molecular Probes
• Oncogenes