Article
Clinical features and genotype-phenotype correlations in 41 Italian families with adenomatosis coli.
Italian journal of gastroenterology and hepatology - 1 Dec 1999
Ponz de Leon M, Benatti P, Percesepe A, Cacciatore A, Sassatelli R, Bertoni G, Sabadini G, Varesco L, Gismondi V, Mareni C, Montera M, Di Gregorio C, Landi P, Roncucci L
Abstract excerpt
BACKGROUND: Familial Adenomatous Polyposis in an autosomal dominant disease in which the large bowel is carpeted by polyps of various dimensions appearing during the second or third decade of life. Several extracolonic manifestations complete the clinical spectrum of Familial Adenomatous Polyposis. If untreated, the disease leads invariably to colorectal cancer. The gene responsible for the disease, adenomatous...
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