Article
Hereditary flat adenoma syndrome: a variant of familial adenomatous polyposis?
Diseases of the colon and rectum - 1 May 1992
Lynch H T, Smyrk T C, Watson P, Lanspa S J, Lynch P M, Jenkins J X, Rouse J, Cavalieri J, Howard L, Lynch J
Abstract excerpt
We describe the clinical and pathologic features in four extended kindreds that are consistent with the hereditary flat adenoma syndrome (HFAS). This colon cancer susceptibility disorder is believed to be inherited as an autosomal dominant. The principal phenotypic marker is multiple colonic aden...
Topics
- Adenoma
- Adenomatous Polyposis Coli
- Adult
- Aged
- Aged, 80 and over
- Causality
- Chromosomes, Human, Pair 5
- Colonic Neoplasms
- Female
- Genetic Linkage
- Humans
- Male
- Middle Aged
- Mutation
- Neoplasms, Multiple Primary
- Pedigree
- Prospective Studies
- Retrospective Studies