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Article

Phosphorylation of the Twist1-family basic helix-loop-helix transcription factors is involved in pathological cardiac remodeling.

PloS one - 29 Apr 2011

Lu Shuangshuang, Nie Junwei, Luan Qing, Feng Qiuting, Xiao Qi, Chang Zai, Shan Congjia, Hess Daniel, Hemmings Brian A, Yang Zhongzhou

Abstract excerpt

BACKGROUND: The Twist1-family basic helix-loop-helix (bHLH) transcription factors including Twist1, Hand1 and Hand2, play an essential role in heart development and are implicated in pathological heart remodeling. Previously, it was reported that these bHLH transcription factors can be regulated by phosphorylation within the basic-helix I domain, which is involved in developmental processes such as limb formation...

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Identifiers

PMID: 21559426
DOI: 10.1371/journal.pone.0019251
PMCID: PMC3084786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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