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Article

Modeling Initiation of Ewing Sarcoma in Human Neural Crest Cells

29 Apr 2011

Abstract excerpt

Ewing sarcoma family tumors (ESFT) are aggressive bone and soft tissue tumors that express EWS-ETS fusion genes as driver mutations. Although the histogenesis of ESFT is controversial, mesenchymal (MSC) and/or neural crest (NCSC) stem cells have been implicated as cells of origin. For the current study we evaluated the consequences of EWS-FLI1 expression in human embryonic stem cell-derived NCSC (hNCSC). Ectopic...

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PMID: 21559395
DOI: 10.1371/journal.pone.0019305

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