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Article

The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells.

Cancer cell - 1 Feb 2008

Joseph Nancy M, Mosher Jack T, Buchstaller Johanna, Snider Paige, McKeever Paul E, Lim Megan, Conway Simon J, Parada Luis F, Zhu Yuan, Morrison Sean J

Abstract excerpt

Neurofibromatosis is caused by the loss of neurofibromin (Nf1), leading to peripheral nervous system (PNS) tumors, including neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs). A long-standing question has been whether these tumors arise from neural crest stem cells (NCSCs) or differentiated glia. Germline or conditional Nf1 deficiency caused a transient increase in NCSC frequency and...

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Identifiers

PMID: 18242513
DOI: 10.1016/j.ccr.2008.01.003
PMCID: PMC2566828

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