Article
Functional analysis of hyperthermophilic endocellulase from Pyrococcus horikoshii by crystallographic snapshots.
The Biochemical journal - 15 Jul 2011
Kim Han-Woo, Ishikawa Kazuhiko
Abstract excerpt
A hyperthermophilic membrane-related β-1,4-endoglucanase (family 5, cellulase) of the archaeon Pyrococcus horikoshii was found to be capable of hydrolysing cellulose at high temperatures. The hyperthermophilic cellulase has promise for applications in biomass utilization. To clarify its detailed function, we determined the crystal structures of mutants of the enzyme in complex with either the substrate or product...
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