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Article

Effect of apolipoprotein E polymorphism on statin-induced decreases in plasma lipids and cardiovascular events.

Drug metabolism and drug interactions - 1 Jan 2011

Hubacek Jaroslav A, Vrablik Michal

Abstract excerpt

Hypercholesterolemia or dyslipidemia is an independent risk factor for cardiovascular disease and statins (inhibitors of a key enzyme of cholesterol synthesis, 3-hydroxymethyl glutaryl coenzyme A reductase) are the drugs of choice for decreasing plasma cholesterol. It has been estimated that genetic factors can explain 40%-60% of final cholesterol concentrations and approximately 70% of the efficacy of statin...

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Source

Identifiers

PMID: 21557673
DOI: 10.1515/DMDI.2011.107

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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