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Article

Apolipoprotein E genotype as a most significant predictor of lipid response at lipid-lowering therapy: mechanistic and clinical studies.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Dec 2011

Dergunov A D

Abstract excerpt

APOE alleles and apolipoprotein E isoforms control plasma cholesterol level on population level. Among three ɛ2, ɛ3, ɛ4 alleles, ɛ4 allele is associated with the increase in cholesterol level, risk of atherosclerosis and Alzheimer disease, while ɛ2 allele is associated with the decrease in cholesterol level and risk of atherosclerosis. The increase in plasma triglyceride is an independent risk factor of...

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Source

Identifiers

PMID: 21705182
DOI: 10.1016/j.biopha.2011.04.003

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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